Hyperthyroidism, but not hypertension, impairs PITX2 expression leading to Wnt-microRNA-ion channel remodeling.

Lozano-Velasco E, Wangensteen R, Quesada A, Garcia-Padilla C, Osorio JA, Ruiz-Torres MD, Aranega A, Franco D.

PLos One. 2017

Pitx2 in Embryonic and Adult Myogenesis.

Hernandez-Torres F, Rodríguez-Outeiriño L, Franco D, Aranega AE.

Front Cell Dev Biol. 2017

More than Just a Simple Cardiac Envelope; Cellular Contributions of the Epicardium.

Dueñas A, Aranega AE, Franco D.

Front Cell Dev Biol. 2017

A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics.

Le Garrec JF, Domínguez JN, Desgrange A, Ivanovitch KD, Raphaël E, Bangham JA, Torres M, Coen E, Mohun TJ, Meilhac SM.

eLife. 2017

Pitx2 impairs calcium handling in a dose-dependent manner by modulating Wnt signalling.

Lozano-Velasco E, Hernández-Torres F, Daimi H, Serra SA, Herraiz A, Hove-Madsen L, Aránega A, Franco D.

Cardiovasc Res. 2016 

Analysis of microRNA Microarrays in Cardiogenesis.

Franco D, Bonet F, Hernandez-Torres F, Lozano-Velasco E, Esteban FJ, Aranega AE.

Methods Mol Biol. 2016

Reciprocal repression between Fgf8 and miR-133 regulates cardiac induction through Bmp2 signaling.

Lopez-Sanchez C, Franco D, Bonet F, Garcia-Lopez V, Aranega A, Garcia-Martinez V.

Data Brief. 2015

miR-27 and miR-125 Distinctly Regulate Muscle-Enriched Transcription Factors in Cardiac and Skeletal Myocytes.

Lozano-Velasco E, Galiano-Torres J, Jodar-Garcia A, Aranega AE, Franco D.

Biomed Res Int. 2015

MiR-23b and miR-199a impair epithelial-to-mesenchymal transition during atrioventricular endocardial cushion formation.

Bonet F, Dueñas Á, López-Sánchez C, García-Martínez V, Aránega AE, Franco D.

Dev Dyn. 2015


Negative Fgf8-Bmp2 feed-back is regulated by miR-130 during early cardiac specification.

Lopez-Sanchez C, Franco D, Bonet F, Garcia-Lopez V, Aranega A, Garcia-Martinez V.

Dev Biol. 2015


A Pitx2-MicroRNA Pathway Modulates Cell Proliferation in Myoblasts and Skeletal-Muscle Satellite Cells and Promotes Their Commitment to a Myogenic Cell Fate.

Lozano-Velasco E, Vallejo D, Esteban FJ, Doherty C, Hernández-Torres F, Franco D, Aránega AE.

Mol Cell Biol. 2015


Expression patterns and immunohistochemical localization of PITX2B transcription factor in the developing mouse heart.

Hernandez-Torres F, Franco D, Aranega AE, Navarro F.

Int J Dev Biol. 2015

Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP.

Aguirre LA, Alonso ME, Badía-Careaga C, Rollán I, Arias C, Fernández-Miñán A, López-Jiménez E, Aránega A, Gómez-Skarmeta JL, Franco D, Manzanares M.

BMC Biol. 2015

Absence of family history and phenotype-genotype correlation in pediatric Brugada syndrome: more burden to bear in clinical and genetic diagnosis.

Daimi H, Khelil AH, Ben Hamda K, Aranega A, Chibani JB, Franco D.

Pediatr Cardiol. 2015


Regulation of SCN5A by microRNAs: miR-219 modulates SCN5A transcript expression and the effects of flecainide intoxication in mice.

Daimi H, Lozano-Velasco E, Haj Khelil A, Chibani JB, Barana A, Amorós I, González de la Fuente M, Caballero R, Aranega A, Franco D.

Heart Rhythm. 2015


Identification of regulatory elements directing miR-23a-miR-27a-miR-24-2 transcriptional regulation in response to muscle hypertrophic stimuli.

Hernandez-Torres F, Aranega AE, Franco D.

Biochim Biophys Acta. 2014

Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.

Rana MS, Théveniau-Ruissy M, De Bono C, Mesbah K, Francou A, Rammah M, Domínguez JN, Roux M, Laforest B, Anderson RH, Mohun T, Zaffran S, Christoffels VM, Kelly RG.

Circ Res. 2014

Arid3b is essential for second heart field cell deployment and heart patterning.

Uribe V, Badía-Careaga C, Casanova JC, Domínguez JN, de la Pompa JL, Sanz-Ezquerro JJ.

Development. 2014 

Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis.

de la Rosa AJ, Domínguez JN, Sedmera D, Sankova B, Hove-Madsen L, Franco D, Aránega AE.

Cardiovasc Res. 2013


Comparative Analyses of MicroRNA Microarrays during Cardiogenesis: Functional Perspectives.

Bonet F, Hernandez-Torres F, Esteban FJ, Aranega A, Franco D.

Microarrays (Basel). 2013

Cardiac conduction system anomalies and sudden cardiac death: insights from murine models.

Aránega A, De La Rosa AJ, Franco D.

Front Physiol. 2012 

Asymmetric fate of the posterior part of the second heart field results in unexpected left/right contributions to both poles of the heart.

Domínguez JN, Meilhac SM, Bland YS, Buckingham ME, Brown NA.

Circ Res. 2012

Transgenic insights linking pitx2 and atrial arrhythmias.

Franco D, Chinchilla A, Aránega AE.

Front Physiol. 2012


Pitx2c modulates Pax3+/Pax7+ cell populations and regulates Pax3 expression by repressing miR27 expression during myogenesis.

Lozano-Velasco E, Contreras A, Crist C, Hernández-Torres F, Franco D, Aránega AE.

Dev Biol. 2011


PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.

Chinchilla A, Daimi H, Lozano-Velasco E, Dominguez JN, Caballero R, Delpón E, Tamargo J, Cinca J, Hove-Madsen L, Aranega AE, Franco D.

Circ Cardiovasc Genet. 2011 

Modulation of conductive elements by Pitx2 and their impact on atrial arrhythmogenesis.

Franco D, Chinchilla A, Daimi H, Dominguez JN, Aránega A.

Cardiovasc Res. 2011


Pitx2c modulates cardiac-specific transcription factors networks in differentiating cardiomyocytes from murine embryonic stem cells.

Lozano-Velasco E, Chinchilla A, Martínez-Fernández S, Hernández-Torres F, Navarro F, Lyons GE, Franco D, Aránega AE.

Cells Tissues Organs. 2011